People

Michael Woodside, Principal Investigator
Professor, Department of Physics
Member, Li Ka Shing Institute of Virology
Member, Centre for Prions and Protein Folding Diseases
michael.woodside[AT]ualberta.ca

 

Krishna Neupane, Research Associate
kneupane[AT]ualberta.ca

I am interested in structure formation and dynamics of biomolecules. Some projects include: misfolding of the protein superoxide dismutase, associated with ALS disease; dynamics of eukaryotic ribosome during programmed frameshifting at stimulatory RNA structures (e.g. a pseudoknot), associated with many viral infections such as HIV; and dynamics of folding at the level of transition paths.

 

Chunhua Dong, Research Associate
chunhua[AT]ualberta.ca

My research interests include quantitative characterization with scanning probe microscopies for the study at nanoscale of nanomaterials and nanosystems: magnetic properties for bio-applications, as well as the study of oligomer formation and mechanism during the progression of Parkinson’s Disease.

 

Craig Garen, Technician
cgaren[AT]ualberta.ca

My research includes using molecular biology and protein biochemistry techniques to aid in the biophysical characterization of protein misfolding and aggregation in neurodegenerative disorders. This includes human superoxide dismutase (amyotrophic lateral sclerosis) and prion protein (spongiform encephalopathies).

 

Abhishek Narayan, Postdoctoral Fellow
narayan1[AT]ualberta.ca

We explore the misfolding of SOD1 (superoxide dismutase 1), a prominent cause for fatal neurological disease familial ALS (amyotrophic lateral sclerosis), in terms of general questions related to protein misfolding and aggregation and its medical relevance. Specifically, we are interested in answering questions like how SOD1 misfolds and spreads, why specific mutations lead to disease, and how different mutations change patient survival times, hampering searches for cures. Moreover, it has been observed that misfolded SOD1 propagates within a single cell and from one cell to other resulting in misfolding of properly folded protein molecules, a feature similar to propagation of prion-disease. Hence, we also aim to decipher the structural features of SOD1 and its mutants responsible for the propagation of misfolding.

 

Simanta Paul, Postdoctoral Fellow
simanta[AT]ualberta.ca

I am studying the early stages of aggregation of proteins involved in neurodegenerative diseases like α-synuclein (Parkinson’s), PrP (prion diseases), aβ and tau (Alzheimer’s) by using single molecule techniques.

 

Sneha Munshi, Postdoctoral Fellow
munshi1[AT]ualberta.ca

The oligomers formed due to misfolding in α-synuclein are a leading cause of neurodegenerative Parkinson’s disease. My project aims to screen the potent inhibitors of oligomers using solution and in-cell (neuroblastoma cell lines) FCCS.

 

Anita Devi, Postdoctoral Fellow
adevi[AT]ualberta.ca

My research focuses on evolution shapes protein folding by measuring transition paths in single molecule spectroscopy.

 

Shubhadeep Patra, Graduate Student
shubhade[AT]ualberta.ca

My research focus is on the study of interactions between Prion protein and anti-prion compounds for understanding the mechanisms of action such as changes in energy landscape, barrier height and location, rates, number and properties of intermediates.

 

Aaron Lyons, Graduate Student
alyons[AT]ualberta.ca

My research focuses on the statistical characterization and analysis of single-molecule force spectroscopy data.

 

Rohith Vedhthaanth Sekar, Graduate Student
rohithve[AT]ualberta.ca

Glycosylation is a post translational modification to the prion protein. I am interested in investigating the effects of glycosylation in the prion folding/misfolding using both computational (molecular dynamics) and experimental techniques.

 

Daniiar Zhaguparov, Graduate Student
zhagupar[AT]ualberta.ca

My research focuses on the understanding the influence of folded exoribonuclease-resistant viral RNA on its resistant properties. The second project involves a study of ribosomal dynamics during -1 programmed translational frameshifting using single molecule force spectroscopy.

 

Fatima Afkhami, Graduate Student
afkhami[AT]ualberta.ca

Aggregation of TDP-43 proteins in the central nervous system is a characteristic of ALS. My research interest is investigating TDP-43 protein with optical tweezers on the level of individual molecule.

 

Bahar Hamzeh, Graduate Student
bhamzeh[AT]ualberta.ca

My research is based on studying proper structures that decrease or even stop the process of misfolding SOD enzymes which is the most important cause of a progressive nervous system disease named ALS (Amyotrophic Lateral Sclerosis).

 

Sandaru Ileperuma, Research Assistant
ileperum[AT]ualberta.ca

The Programmed Ribosomal Frameshifting sequence is a relatively conserved element in SARS-Cov2 which is required for the virus to function properly and thus drugs targeting the frameshifting element could hinder viral propagation. My work aims to identify these potential drug candidates experimentally through the use of luciferase assays with compounds which have been tested computationally against the SARS-Cov2 frameshifting element . These drugs are also tested on a wide range of bat coronavirus pseudo-knots in hopes of discovering a pan-coronaviral therapeutic approach to dealing with future and current coronavirus pandemics.